I wish to report some evidence that may have an important bearing on
the treatment of beta-thalassemia (thalassemia major, Cooley's anemia,
Mediterranean anemia) and sickle cell disease. A wheatgrass extract I
use frequently in clinical practice may well have the potential to
improve the quality of life of many sufferers of this debilitating,
often life-threatening disorder. There is both clinical evidence and
some state-of-the-art science that supports this finding.
Thalassemia major is an inherited disorder of hemoglobin, the protein
in red blood cells that binds oxygen and transports it around the body.
Just one gene determines whether or not a child will have the disorder
or is simply a carrier of the abnormal gene. The disorder affects
children of mainly South-East Asian (eg. 600,000 cases in Thailand),
Indian, Mediterranean and Central African origin. Patients can suffer
from an enlarged liver and spleen, heart failure, growth retardation,
endocrine disorders and various other symptoms. Current treatment for
thalassemics includes regular blood transfusion, chelating or
iron-removing drugs, and drugs that induce the production of fetal
hemoglobin such as hydroxyurea. Without adequate support and management,
the disease can be fatal.
Wheatgrass and other cereal grasses have been thoroughly researched
and reported as a therapeutically effective substance since the 1930's.
Traditionally, chlorophyll, or its synthetic derivative, chlorophyllin,
has been implicated as the biological active responsible for reported
healing effects. A number of animal studies have shown quite marked
improvement in anemia following chlorophyll ingestion. (1,2,3). Other
studies up to the present day have shown positive results in the
treatment of suppurating wounds(4), burns(5), liver cancer(6),
ulcerative colitis(7) and many other conditions. My own experiences in
treating numerous patients with a wheatgrass extract since 1995,
although anecdotal, strongly support many of these research findings. I
am almost certain however that neither chlorophyll nor chlorophyllin is
the therapeutic agent responsible.
In my
February, 2004 newsletter,
I mentioned a clinical pilot study carried out by Dr. R. K. Marwaha et
al at the Advanced Pediatric Centre, Postgraduate Institute of Medical
Education and Research, Chandigarh, India. Entitled
"Wheat grass juice reduces transfusion requirement in patients with thalassemia major: a pilot study.",
the study was performed between February 2000 and May 2003. Sixteen out
of 38 (42%) blood transfusion dependent thalassemics fulfilled the
trial criteria for final analysis.
To summarise the findings during period of wheatgrass juice ingestion:
- all participants experienced lower blood transfusion requirements (from 0.4 to 43%)
- 50% had at least 25% reduction in transfusion requirements
- the mean interval between transfusions increased 29.5%
- overall, hemoglobin levels were not compromised by reduced transfusion volumes
Dr. Marwaha's conclusion was that "wheat grass juice has the potential to lower transfusion requirements in thalassemics."
He was not prepared to speculate on the "mechanism of action of wheat
grass juice in transfusion dependent thalassemics" being of the opinion
that the concept of chlorophyll enhancing hemoglobin production "sounds
too simplistic". I support his position and seriously doubt whether
chlorophyll has any function other than to drive photosynthesis. (See my
newsletter
"Chlorophyll - Healer or Humbug").
Add to this the fact that my wheatgrass extract is clinically effective
in most, if not all the areas described in the substantial literature
about wheatgrass healing - but contains
barely detectable amounts of chlorophyll.
It is interesting to note that twenty of the original trial participants were withdrawn due to
"indiscipline in intake and an insufficient duration of intake of wheat grass juice."
This does not surprise me considering they were asked to consume 100mls
per day. Many find fresh wheatgrass juice unpalatable, as I do. Some of
these children were as young as four and, unless they really enjoyed
the taste, would have found it very difficult to comply with the regime.
They would I believe, have found it much easier to ingest a dilute
solution of my extract.
I contacted Dr. Marwaha, mentioning the extract and wheatgrass
website. At the time it did not seem likely he would want to repeat or
extend the pilot study using the extract, so I did not suggest it.
Nonetheless, because of the substantial clinical experience I have had
using wheatgrass as a therapeutic agent and the extensive scientific
literature available on the topic, I felt quite certain that it would
work just as well as fresh wheatgrass juice. More importantly, the
extract is infinitely more palatable and the dose required would amount
to
no more than 1 to 3 mls. a day. Also, wheatgrass
cultivation is unnecessary as the extract's potency lasts for years, if
not indefinitely. The next development was totally unexpected.
The
Murdoch Children's Research Institute
at the Royal Children's Hospital in Melbourne (Australia) is involved
in a number of research projects, one of which is thalassemia. This
unit, the Cell & Gene Therapy Research Group is headed by Professor
Panos Ioannou who has spent a large part of his working life researching
thalassemia. Also, because of his work in the production of artificial
chromosomes, he made a significant contribution to the Human Genome
Project. On 3rd May he requested a sample of wheatgrass extract saying,
"We have recently developed
very specific assays for the induction of foetal haemoglobin, ("
The
assay is based on detecting production of HbF in human erythroleukaemia
cells using a fluorescent protein gene that is used to replace the
genes for HbF") to facilitate the discovery of pharmacological
agents that might be therapeutic for thalassaemia. Given the reported
effects of wheatgrass juice on thalassaemia, (
Dr. Marwaha's pilot study) we would very much like to test wheatgrass juice (
extract) whether it can cause a significant increase in foetal haemoglobin."
This point is important. Fetal hemoglobin, (HbF) which has a
substantially higher affinity for oxygen than adult hemoglobin, develops
in the fetus during the last six months of gestation. As both mother
and fetus share the same blood supply, fetal hemoglobin essentially
draws off oxygen from the mother's blood. This enables the fetus to
survive in the uterus. After birth, fetal hemoglobin levels fall rapidly
and in the adult represents less than two percent of total hemoglobin
in the body. It has been found that stimulation or induction of fetal
hemoglobin in thalassemia can improve the patient's clinical condition.
Although drugs exist that have this function, e.g. hydroxyurea, they
lack specificity and may have a variety of serious side effects.
Professor Ioannou assayed the wheatgrass extract for fetal hemoglobin
induction on three separate human cell clones.
On 14 July he reported
that
over a 5 day period:"Our measurements suggest a 3-5 fold increase in the
production of HbF by the wheat grass extract. This is a substantial
increase and could certainly provide an explanation why some
thalassaemia patients may derive significant benefit."
Of course, these laboratory results may or may not bear a
relationship to what one could expect in the thalassemic patient.
However, given the quite significant reduction in transfusion
requirements noted in some of the patients in Dr. Marwaha's pilot study,
Professor Ioannou's findings strongly suggest they could have resulted
from induction of fetal hemoglobin by wheatgrass.
I think it is worth noting again that the Murdoch Institute results were achieved using a wheatgrass extract that
contained virtually no chlorophyll. This
fact further supports my belief that chlorophyll, like hemoglobin, has a
specific function to perform in nature. As hemoglobin transports oxygen
within the red blood cell, so does chlorophyll assist photosynthesis
within the chloroplast. Nothing more, nothing less.
In conclusion, I believe the two new studies relating to wheatgrass
and induction of fetal hemoglobin mentioned here give more than a
glimmer of hope to thalassemic patients. Commercial wheatgrass products
such as fresh juice, tablets, powders and nutritional supplements are
cheap, readily available and virtually devoid of adverse effects. While
more studies are clearly necessary, thalassemics may have nothing to
lose and possibly much to gain from ingesting wheatgrass, in one form or
another, daily. While it is not possible from the current studies to
predict the optimal dose of wheatgrass extract for a beneficial effect
on thalassaemia, I recommend that in order to benefit fully from the
biological activity of the herb, thalassemics, like anyone taking
wheatgrass, need to hold it in the mouth for at least a minute before
swallowing.
References:
- Kirkman, N.F. 1939. The effect of low-porphyrin diet on erythropoiesis and hemoglobin regeneration. J Physiol 95:508-515
- Kelentei, B., Fekete, I., Kun, F. 1958. Influence of copper chlorophyllin on experimental anemia. Acta Pharm Hung 28:176-180
- Borisenko, A.N., Sofonova, A.D. 1965. Hemopoietic effect of Na chlorophyllin. Vrach Delo 9:44-46
- Gruskin, B. Chlorophyll – its therapeutic place in acute and suppurative disease. 1940. American Journal of Surgery.
- Collings, G. 1945. Chlorophyll and adrenal cortical extract in the
local treatment of burns. American Journal of Surgery 70:58- 63.
- Egner, P.A., Munoz, A., Kensler, T.W. 2003. Chemoprevention with
chlorophyllin in individuals exposed to dietary aflatoxin. Mutat Res.
2003 Feb-Mar;523-524:209-16.
- Ben-Ayre, E., Goldin, E., Wengrower, D., Stamper, A., Kohn, R.,
Berry , E. 2002. Wheat grass juice in the treatment of active distal
ulcerative colitis: a randomized double-blind placebo-controlled trial.
Scand J Gastroenterol 2002;37:444-449
(Source:www.drwheatgrass.com)
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